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Hepatic biotransformation of MLN8054 was examined in vitro using human liver S9 fractions (Details on file, Millennium). Glucuronidation in the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation in the azepine moiety of MLN8054 was the key period 1 biotransformation pathway. Glucur
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